The TADS trial closed enrollment on July 31st, 2003.

What Is TADS?….

The Treatment for Adolescents with Depression Study, TADS, is a research study of treatments for Major Depressive Disorder in teenagers. TADS will compare the short- and longer-term effectiveness of medication and psychotherapy for depression, also known as Major Depressive Disorder, in teenagers. For teens treated in TADS, the trial is designed to provide best-practice practical care for depression. It is our hope that the overall study results will improve the future care of adolescents with depression.

Major depressive disorder (MDD) is a mood disorder that can alter thoughts, feelings and behavior. In particular, teens with MDD often:

  • are sad, blue, irritable and/or complain that nothing is fun anymore
  • have trouble sleeping, low energy, poor appetite and trouble concentrating
  • become socially withdrawn or perform more poorly in school
  • can be suicidal

About 4% of teenagers have major depression at any one time. Among teens, girls are more often affected than boys. MDD frequently interferes with home, school and family life, including causing a lot of family stress. Suicide is the third leading cause of death among teenagers, with about half of these associated with depression. This makes depression a common and serious illness that is important to identify and treat early in the course of the disease. To understand which treatments work best for which depressed teenagers, TADS is comparing different treatments for major depression in teens, with the goal of improving the treatment and outcomes of young persons with this disorder.

General Information About Depression

The following two links provide comprehensive general information about depression.


You have entered a web site that describes an NIMH-funded collaborative study on the treatment of adolescents with depression. If you are seeking immediate help for treatment of depression, we recommend that you contact your clinician or your nearest emergency room. This web site is not set up to provide help or advice to individuals about their depression, nor to family members or friends of individuals with depression.

If you are interested in getting general information about depression, you can visit the following web site:

This web site is created solely for the purposes of providing background information about the study and having researchers provide input to the design.

This web site does not provide a chat room and individual queries will not receive a response. Any message posted on this web site is not confidential.